Rapid, large-volume intravenous rehydration for outpatients with dehydration did not show any benefit over more standard regimens. Clinical guidelines incorporate all these aspects
of care; however, physicians show poor adherence to the guidelines despite the evidence that guidelines improve outcomes and reduce cost.
Dehydration burdens the healthcare system worldwide. Through advances in its assessment, treatment with antiemetics and intravenous fluids, and standardization of practice with clinical guidelines, this burden could be reduced.”
“Purpose of reviewThe management of nonmuscle invasive bladder cancer (NMIBC) recurrent PU-H71 manufacturer after bacillus Calmette-Guerin therapy is complex and further complicated by high numbers of patients who are not candidates for cystectomy. This article reviews data supporting the use EPZ5676 of chemoradiation in NMIBC and discusses emerging biomarkers of treatment response.Recent findingsRadiotherapy, especially when combined with chemotherapy, has shown great promise for treating bladder cancer. Recent studies have identified that many patients with bladder cancer
do not receive potentially curative therapies. Many such patients are elderly or infirm and represent an unmet need for curative therapeutic alternatives to radical cystectomy. Although radiotherapy alone does not appear superior to intravesical therapy in NMIBC, at least one series Idasanutlin in vivo with long-term follow-up has shown excellent results in patients treated with radiation and concurrent chemotherapy. A clinical trial investigating the role for chemoradiation in T1 disease that has recurred is underway. Biomarkers able to predict radiotherapy response may allow for personalized therapy in the near future.SummaryChemoradiation is an emerging treatment option for selected patients with NMIBC.
Prospective validation of currently identified biomarkers is needed along with further research to identify which patients may benefit the most from such therapy.”
“Coal tars have been identified as posing a threat to human health due to their toxic, mutagenic and carcinogenic characteristics. Workers involved in former gasholders decommissioning are potentially exposed to relevant concentrations of volatile and semi-volatile hydrocarbons upon opening up derelict tanks and during tar excavation/removal. While information on contaminated sites air-quality and its implications on medium-long term exposure is available, acute exposure issues associated with the execution of critical tasks are less understood. Calculations indicated that the concentration of a given contaminant in the gasholder vapour phase only depends on the coal tar composition, being only barely affected by the presence of water in the gasholder and the tar volume/void space ratio.