Good control of the HIV infection and the regular use of ART by

the majority of the women may have brought this group of women closer to the HIV-negative group in terms of their characteristics. Conclusions In this study population, HIV infection was not associated with the presence of dyspareunia. The principal factors associated Imatinib Sigma with dyspareunia in HIV-positive women were vaginal dryness and urinary incontinence. These data indicate a need for multidisciplinary care for HIV-positive menopausal women, paying particular attention to ensuring the women’s compliance with ART and offering improved care when these two clinical situations are present to ensure that these women come as close as possible in this respect to HIV-negative women. Greater attention to dyspareunia as a potential component of women’s general HIV and sexual care is warranted. A

proactive approach to conversations about vulvovaginal atrophy would improve the management of dyspareunia and vaginal dryness. In addition to improving the quality of these women’s sexual lives, we hypothesise that appropriate management of this issue may reduce the likelihood of lesions on the vaginal wall, which may act as a portal of entry for other infections. Supplementary Material Author’s manuscript: Click here to view.(1.3M, pdf) Reviewer comments: Click here to view.(159K, pdf) Footnotes Collaborators: Lívia Akl helped in the collection of data. Contributors: ALRV, AMP-N and

LC-P contributed to the conception or design. ALRV, DdCG, WCD and ASM contributed to the acquisition of data. MHdS, ALRV, AMP-N and LC-P contributed in the analysis of data. ALRV, AMP-N, LC-P and MHdS contributed in the interpretation of data. All the authors were involved in the drafting of the manuscript or revising it critically for intellectual content. All the authors gave final approval of the version to be published. Funding: The São Paulo Foundation for the Support of Research (Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP), Grant # 2010/06037-5. Competing interests: None. Patient Dacomitinib consent: Obtained. Ethics approval: The project was approved by the internal review board of CAISM/UNICAMP and was conducted in compliance with the current version of the Declaration of Helsinki and with Resolution 196/96 of the Brazilian National Committee for Ethics in Research (CONEP) and its subsequent revisions. Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: We have used a questionnaire to collect data for this study. The instrument used to collect data is available by emailing [email protected]
We conducted a nested case–control study based on all residents in Denmark (approximately 5.6 million).