Given this conclusion, the activation spreading may require low activation amplitudes if not directly affected by the activation increase caused by “dual activation.” This effortless and efficient type of spreading may conform to automatic spreading of activation as suggested by Neely (1991). This is corroborated by the restriction of significant neural priming to a rostral part of ACC for categorical distractors (see Inhibitors,research,lifescience,medical Figs. 3, ​,6),6), which can be attributed to lower demands on controlled but not on automated processing. The right medial temporooccipital gyrus

was reduced to a minor extent for both distractors sharing semantic relationships, and to the same degree for the combination of all distractors. This area has been associated with visual processing (see above). In BI-6727 general, an overlap of semantic networks may be difficult to observe, as meaning is more widely distributed in the brain (Wible et al. 2006). Nevertheless, for associative and categorical distractors Inhibitors,research,lifescience,medical there was nonoverlapping deactivation of the middle section of right STG. For associative distractors, middle and posterior sections

of left STG were also suppressed. In turn, STG has previously been Inhibitors,research,lifescience,medical shown to receive dual activation for phonological distractors (Abel et al. 2009a; see Fig. S1). Suppression of STG due to semantic priming (Rissman et al. 2003; Matsumoto et al. 2005; Wible et al. 2006) and categorical/phonological interference (De Zubicaray and McMahon 2009), as well as a correlation between behavioral Inhibitors,research,lifescience,medical priming in a semantic task and suppression in right STG (Bergerbest et al. 2004) previously

have been reported. We assume that STG deactivation may reveal efficient activation spreading from (lexical-) semantics to lexical-phonological entries. Thus, lower activation is required to access semantically related word pairs from the phonological lexicon, than there is for a pair of unrelated entries (high demands) Inhibitors,research,lifescience,medical with separate meanings. These results are in accordance with assumptions about two divergent cognitive mechanisms in semantic interference: The spreading of activation and the selection of the target (e.g., Finkbeiner and Caramazza 2006). We conclude that the relation between cognitive and neural processing may be as follows: For associative distractors, the selection however of the target (IFG deactivation in the present study) requires low effort while there is spreading of activation (to STG), leading to fast RTs in picture naming. Categorical distractors share the spreading of activation, but there are strong demands on the selection process, leading to slower RTs. Moreover, brain areas related to conflict processing are strongly involved, including portions of the ACC that has been associated with monitoring and slowing of responses (Botvinick et al. 2004).