A common genetic polymorphism, the Taq 1B, influences CETP activi

A common genetic polymorphism, the Taq 1B, influences CETP activity and HDL-cholesterol levels, with individual homozygotes for the B1 allele exhibiting higher enzyme activity and lower HDL-cholesterol levels than carriers of at least one B2 allele. Our aim was to analyze

the influence of Taq 1B CETP polymorphism on cardiovascular risk factors in a representative sample of adult subjects from Canary population.

Methods and result: A total of 518 adult subjects from the Canary Islands, enrolled in a nutritional survey (the ENCA study), were included. The Taq 1B polymorphism was analyzed by PCR-RFLP. Compared Dihydrotestosterone purchase with individuals with at least one B2 allele, and after adjusting for age, sex, BMI, waist perimeter, smoking and alcohol intake, carriers of the B1B1 genotype showed lower HDL-cholesterol levels (geometric mean (95% CI): 46.6 (44.5-48.8) vs. 50.6 (49.1-52.9) mg/dl; P = 0.003); and higher insulin (geometric mean (95% CI): 11.1 (10.5-11.9) vs. 10.0 (9.5-10.5 mU/ml; P = 0.008) and HOMA levels (geometric mean (95% CI): 2.3 (2.1-2.5) vs. 2.1 (1.9-2.1); check details P = 0.009). In addition, the B1B1 genotype was more frequent in individuals who had low

levels of HDL-cholesterol according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria (Odds Ratio (OR): 1.563; 95% CI: 1.04-2.34; P = 0.030), and in those included in the upper quartile of insulinemia (OR: 1.90; 95% CI: 1.20-3.03; P = 0.007) and HOMA (OR: 1.61; 95% CI: 1.02-2.57; P = 0.043).

Conclusion: The observed influence of Taq 1B polymorphism on insulin levels and HOMA highlights the possible role of CETP learn more in the regulation of glucose homeostasis. (C) 2009 Elsevier B. V. All rights reserved.”
“Objectives. The aim of this study was to evaluate the gustatory function of patients with diabetes mellitus type 2 and to compare gustatory appreciation on right and left sides of the tongue and soft palate.

Study design. The study group was composed of 40 controlled and 40 uncontrolled diabetes

mellitus type 2 patients. A group of 40 age-and gender-matched healthy control subjects were also evaluated. Gustatory function was tested by administering a whole-mouth above-threshold test and spatial taste test using sucrose, sodium chloride (NaCl), citric acid, and quinine hydrochloride solutions. Statistical analysis was performed using 1-way ANOVA and Student t test.

Results. Taste impairment was found in the controlled and uncontrolled diabetic patients relative to healthy control subjects (P < .0001). A highly significant difference was noticed for sweet (P = .00001) and sour (P = .00002) tastes. For salt taste, a significant difference was found (P = .001). Hypogeusia was reported among 50 (62.5%) of the diabetic patients versus 5 (12.5%) of control subjects (P < .0001). Ageusia to sweet was found in 6 uncontrolled diabetic patients (P < .0001).

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