36 ± 0 18 * 1 61 ± 0 25 † 1 44 ± 0 23 HDL- C (mmol/l) 0 85 ± 0 15

36 ± 0.18 * 1.61 ± 0.25 † 1.44 ± 0.23 HDL- C (mmol/l) 0.85 ± 0.15 * 1.05 ± 0.23   1.00 ± 0.21 HDL- C (mmol/l 0.51 ± 0.08   0.56 ± 0.07 † 0.46

± 0.01 LDL-C (mmol/l) 2.74 ± 0.57   2.80 ± 0.85 † 2.27 ± 0.47 Lp (a) (mmol/l) 0.29 ± 0.32   0.31 ± 0.27   0.24 ± 0.25 TC (mmol/l) 4.37 ± 0.76   4.66 ± 0.97   3.99 ± 0.57 TG (mmol/l) 1.02 ± 0.56   0.87 ± 0.39   0.76 ± 0.23 logTG (mg/dl) 1.90 ± 0.23   1.85 ± 0.19   1.81 ± 0.13 Apo A- (mg/dl) 134.4 ± 18.8   149.6 ± 18.0 † 133.6 ± 17.5 Apo A-I (mg/dl) 30.3 ± 5.7   31.2 ± 4.8 † 26.9 ± 3.5 Apo B (mg/dl) 76.9 ± 15.9 † 78.1 ± 22.6   63.8 ± 12.7 LCAT activity (nmol/ml/h/37 83.3 ± 19.9 † 87.2 ± 20.1 † 65.5 ± 15.0 Values are the mean ± SD. Abbreviations; HDL-C, high-density lipoprotein

cholesterol; LDL-C, low-density lipoprotein cholesterol; Lp, lipoprotein; Apo, apolipoprotein; LCAT activity,lecitin:cholesterol. acyltransferase. *p < 0.05 HKI-272 concentration IWP-2 vs Backs. †p < 0.05 vs Controls. The hematological parameters are shown in Table 5. The forwards had significantly higher mean Ht, MCV, and lower MCHC than the control group. The backs had significantly higher transferring, TIBC, Ht, MCV, and significantly lower haptoglobin than the control group. Four forwards (22%), five backs (31%), and three controls (12%) had hemolysis (data not shown). None of the rugby players or controls had anemia. None of the rugby players had iron depletion, while one of the controls did. Table 5 Hematological parameters of rugby players and controls   Forward   Backs   Controls   (n=18)   (n=16)   (n=26) Ferritin (ng/ml) 73.4 ± 28.8   47.7 ± 17.6   72.0 ± 37.3 Transferrin (mg/dl) 262.8 ± 33.5

  269.1 ± 28.5 † 243.8 ± 31.6 Serum iron (?g/dl) 17.6 ± 7.5   19.3 ± 5.9   19.3 ± 5.9 TIBC (?g/dl) 61.8 ± 7.4   63.6 ± 6.3 † 57.7 ± 7.0 UIBC (?g/dl) 44.2 ± 9.9   44.2 see more ± 7.8   38.4 ± 9.4 Red blood cell (×10000/?l) 503.3 ± 23.2   514.6 ± 19.0   515.7 ± 28.3 Hemoglobin (g/dl) 15.4 ± 0.8   15.8 ± 0.6   16.0 ± 0.9 Hematocrit (%) 50.7 ± 2.5 † 51.9 ± 2.3 † 48.6 ± 2.8 MCV (fl) 100.8 ± 4.3 † 100.9 ± 3.5 † 94.3 ± 3.0 MCH (pg) 30.7 ± 1.5   30.7 ± 0.8   31.0 ± 0.9 MCHC (%) 30.5 ± 0.8 † 30.4 ± 0.7 † 32.9 ± 0.6 Staurosporine in vivo Platelet (×10000/?l) 26.0 ± 4.0 * 21.8 ± 2.7   24.5 ± 3.8 Haptoglobin (mg/dl) 65.8 ± 36.9   51.9 ± 24.0 † 85.2 ± 41.5 Tf% 28.6 ± 12.2   30.5 ± 9.3   34.0 ± 11.1 Values are the mean ± SD. Abbreviations; TIBC, total iron binding capacity; UIBC, unsaturated iron binding capacity; MCV= mean corpuscular volume, MCH, mean conpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; Tf%, saturated transferrin. *p < 0.05 vs Backs. †p < 0.05 vs Controls. Discussion Nutrient intake Lundy et al. [24] reported on the nutrient intake of Australian rugby players, in which the mean daily energy intakes of the forwards and backs were 4309±947 and 4142±822 kcal, respectively.

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