21 ± 2.28 at 144 weeks) than in the ALF group (2.55%/year; 9.21 ± 2.36 at baseline and 9.90 ± 2.71 at 144 weeks). In view of our previous results on BR [25], calculated by the same formula, that the longitudinal change in BR of healthy post-menopausal women younger than the subjects in this study was 1.48 ± 4.81% per year, www.selleckchem.com/products/chir-99021-ct99021-hcl.html it is tempting to speculate that ELD may have countered the age-related increase in BR. The bone geometry and vBMD of the femoral shaft were examined

using an analytical program different from that used to examine the femoral neck. Although it is difficult to compare values obtained using different software, we reasoned that comparison of the results by the percentage changes should be acceptable. T.AR and B.AR in the femoral shaft correspond respectively to total and cortical CSAs of the femoral neck, and OUT.PERI corresponds to cortical perimeter of the femoral neck. The results (Fig. 3) indicate that the changes in geometry of the femoral shaft were very consistent with the features in the femoral neck. Total CSA of the femoral neck increased in both the ALF and ELD groups (Fig. 1), as did T.AR of the femoral shaft (Fig. 3). B.AR of the femoral shaft increased PARP inhibitor trial significantly only in the ELD group (Fig. 3), and cortical CSA of the femoral neck increased more in the ELD group (Fig. 1). OUT.PERI of the femoral shaft increased in both the ALF and ELD groups (Fig. 3), as

did the cortical perimeter of the femoral neck (Fig. 1). Notably, the cortical vBMD of the femoral neck increased in both the ALF and ELD groups, whereas the cortical vBMD of the femoral shaft decreased in both groups. Since the cortex in the femoral neck is very

thin compared to that in the shaft, the partial-volume effect should be taken into account when evaluating the cortical vBMD of the femoral neck. stiripentol However, according to our previous study on age-related changes in the femoral neck and shaft in non-osteoporotic subjects [25], the rate of decrease in cortical vBMD was greater in the femoral shaft than in the femoral neck. It is possible, therefore, that ALF and ELD failed to prevent the rapid decline in cortical density of the femoral shaft. Finally, the present study has limitations. First, the study lacked a placebo group. Second, because our study included very few cases of hip fracture (only one in each group), the relationship of ALF or ELD treatment with the incidence of hip fracture has not been verified. In conclusion, our longitudinal analysis of hip geometry by clinical CT has revealed the advantage of ELD over ALF in maintaining cortical thickness and vBMD of the femoral neck and shaft, probably through mitigating endocortical bone resorption, thereby improving the biomechanical parameters. By maintaining the biomechanical properties of the proximal femur, ELD may have the potential to reduce the risk of hip fracture.