pylori infection, two studies tested the association between H. pylori infection and hyperemesis gravidarum characterized by intractable vomiting in pregnant women [92] and the occurrence GPCR Compound Library of neural tube defects in newborns [93], but the low inclusion rate limited the conclusions to be drawn. The cross-reactivity between anti-H. pylori antibodies and other antigens is one of the hypotheses to explain the role of H. pylori infection in extradigestive disease. Based on this mechanism, Franceschi et al. [94] attempted to explain the epidemiologic association between CagA-positive H. pylori strains and previously reported pre-eclampsia [95-98].

They used placenta samples from healthy women and tested the ability of anti-CagA antibodies AT9283 to recognize trophoblast cells and invasive potential and pro-inflammatory properties of trophoblast cells in the presence or absence of anti-CagA antibodies. Results supported the hypothesis that anti-CagA antibodies recognize cytotrophoblast cells and reduce their invasiveness. Chen et al. [99] in a prospective

cohort analysis with 9895 participants (<41 year) followed for at least 12 years (the National Health and Nutrition examination Survey III) did not conclude that H. pylori infection was a major risk factor for all-cause mortality. In fact, In this cohort, H. pylori positivity (including CagA strains) was not associated with increased all-cause mortality. H. pylori infection was associated with an increased risk of death due to gastric cancer, but with reduced risks of death due to stroke and lung cancer. Over the last year, several diseases have been reported to be associated with H. pylori infection and/or CagA-positive strains. Their role, in some hematologic condition, such as ITP, idiopathic sideropenic anemia, and vitamin B12 deficiency, has been fully validated and included in the current guidelines. There is a positive trend in favor

of an association between H. pylori infection selleck compound and neurodegenerative disorders. Furthermore, there are new data concerning a reduced risk of death due to stroke and lung cancer in patients with H. pylori infection but an increased risk of pre-eclampsia in women infected by CagA-positive strains, which deserves further investigations. Competing interests: the authors have no competing interests. “
“Background:  Many micronutrients depend on a healthy stomach for absorption. Helicobacter pylori chronic gastritis may alter gastric physiology affecting homeostasis of vitamins and minerals. Objectives:  Systematic review to assess whether H. pylori infection is associated with reduced micronutrient levels (other than iron) in the plasma or gastric juice and whether low micronutrient levels are modified by eradication treatment. Method:  Medline was searched for relevant publications from inception to June 2010. Studies describing micronutrient levels in H. pylori-infected and not-infected adults and/or the effect of eradication treatment on micronutrient levels were included.