Murakami A, Ohura S, Nakamura Y, Koshimizu K, Ohigashi H: 1′-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin. Oncology 1996, 53:386–391.PubMedCrossRef 28. Tanaka T, Kawabata K, Kakumoto M, Matsunaga K, Mori Ceritinib H, Murakami A, Kuki W, Takahashi Y, Yonei H, Satoh K, Hara A, Maeda M, Ota T, Odashima S, Koshimizu K, Ohigashi H: Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats. Carcinogenesis 1998, 19:425–431.PubMedCrossRef 29. Ohnishi M, Tanaka T, Makita H, Kawamori T, Mori H, Satoh K, Hara A, Murakami A, Ohigashi H, Koshimizu

K: Chemopreventive effect of a xanthine oxidase inhibitor, 1′-acetoxychavicol acetate,

on rat oral carcinogenesis. Jpn J Cancer Res 1996, 87:349–356.PubMedCrossRef 30. Tanaka T, Kawabata K, Kakumoto M, Makita H, Matsunaga K, Mori Z-VAD-FMK nmr H, Satoh K, Hara A, Murakami A, Koshimizu K, Ohigashi H: Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1′-acetoxychavicol acetate. Jpn J Cancer Res 1997, 88:821–830.PubMedCrossRef 31. Tanaka T, Kawabata K, Kakumoto M, Hara A, Murakami A, Kuki W, Takahashi Y, Yonei H, Maeda M, Ota T, Odashima S, Yamane T, Koshimizu K, Ohigashi H: Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes. Cancer Res 1998, 58:2550–2556.PubMed 32. Ito K, Nakazato T, Murakami CYTH4 A, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Ohigashi H, Ikeda Y, Kizaki M: Induction of apoptosis in human myeloid leukemic cells by 1′-acetoxychavicol acetate through a mitochondrial- and Fas-mediated dual mechanism. Clin Cancer Res 2004, 10:2120–2130.PubMedCrossRef 33. Moffatt J, Hashimoto M, Kojima A, Kennedy DO, Murakami A, Koshimizu K, Ohigashi H, Matsui-Yuasa

I: Apoptosis induced by 1′-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation. Carcinogenesis 2000, 21:2151–2157.PubMedCrossRef 34. Kawabata K, Tanaka T, Yamamoto T, Ushida J, Hara A, Murakami A, Koshimizu K, Ohigashi H, Stoner GD, Mori H: Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1′-acetoxychavicol acetate. Jpn J Cancer Res 2000, 91:148–155.PubMedCrossRef 35. Nakamura Y, Murakami A, Ohto Y, Torikai K, Tanaka T, Ohigashi H: Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1′-acetoxychavicol acetate. Cancer Res 1998, 58:4832–4839.PubMed 36. Campbell CT, Prince M, Landry GM, Kha V, Kleiner HE: Pro-apoptotic effects of 1′-acetoxychavicol acetate in human breast carcinoma cells. Toxicol Lett 2007, 173:151–160.PubMedCrossRef 37.