Let me start by providing, as the

Editors requested, my “life story. The clearest indication of the absence of a grand plan for my personal career development is the fact that Alpelisib in vitro I entered college as a journalism major. I was born and raised in Geneva, New York, and during high school my prime preoccupation was participating in interscholastic sports. I envisioned a career as a sports writer and thus, proudly, became the first in my family to attend college. After one exciting year of traveling with our university’s athletic teams, documenting their successes and failures, I realized that my passion was not to passively observe others addressing challenges, but to be actively involved in solving problems (a player, not an observer). I transferred schools, to a more challenging academic environment and changed my major to biology/biochemistry. This heavy science background combined with a dramatic exposure to the field of medicine led to the “rest of the story.” During my junior undergraduate year Sirolimus I developed mononucleosis and was confined to the university infirmary for what was, even then, an extreme period, almost 2 months. I felt well—but every time I asked my healthcare

providers about their treatment strategy, my prognosis, or the rationale for my “continued observation,” my questions went largely unanswered. There was no subterfuge—they truly did not have evidence on which to base their decision. It is possible that their concern was related to the possibility that, if discharged, I might “spread the disease” around campus—after all, mono was considered to be the “kissing disease”! My frustration blended with extreme respect, fascination, and ultimately enlightenment. During one of those long nights in the infirmary, I reflected on the encounters of the day, and the gaps in basic understanding of a seemingly common disease process and its treatment. Thus, after my release I met with my guidance counselor and expressed my interest in applying to medical school. I was told, ironically, that it was unlikely that my application would be successful given the “set back” of the prolonged confinement! That

“low chance of success” conversation has remained a clear stimulus to me over the years! Two important life-changing events occurred medchemexpress during medical school. Of greatest importance, I met a nursing student, Becky McLeod, who became my wife and my major influence and support (Fig. 1). She has created and maintained stability in my life—allowing me to focus on the work at hand reassured by the fact that Becky has everything else in our lives “under control.” The second event was a summer spent working in the Pediatric Unit at Roswell Park Cancer Institute. This, at times, trying experience left me with a strong impression of the resiliency of a child in the presence of a serious illness. To see a child grow and thrive after surviving a devastating illness led to my decision to become a pediatrician.