In the left ventricle, fibers in the subepicardium run in a left-handed direction, fibers in the mid layer run circumferentially, and

fibers in the subendocardium run in a right-handed direction (Fig. 1). These www.selleckchem.com/products/Camptothecine.html Myocardial fibers are connected to each other, with a smooth transition from subendcardium to mid layer, and then to subepicardium, about the long-axis. Contraction of these three layers of myocardial fibers causes not only longitudinal, circumferential, and radial movements of the heart, but also contortion of the myocardium. Inhibitors,research,lifescience,medical Fig. 1 Myocardial fiber orientation and direction of rotation. Myocardial fibers in the subepicardium helically Inhibitors,research,lifescience,medical run in a left-handed direction, fibers in the mid layer run circumferentially, and fibers in the subendocardium helically run in a right-handed direction. … Myocardial fibers on the subepicardial side run in a left-handed direction, and contraction of these fibers will cause the base to rotate in a clockwise direction and the apex to rotate in a counterclockwise direction. Myocardial fibers on the subendocardial side run in a right-handed direction, and contraction

of these fibers will cause the base Inhibitors,research,lifescience,medical to rotate in a counterclockwise direction and the apex to rotate in a clockwise direction (Fig. 2). This means that rotations caused by the subepicardium and subendocardium are in opposite directions. Why, then, does clockwise rotation of the base and counterclockwise rotation of the apex become significant? In other words, why is it the rotation of the subepicardial side that becomes significant? This is explained by the difference Inhibitors,research,lifescience,medical in the radius of rotation of the subepicardium Inhibitors,research,lifescience,medical and subendocardium (Fig. 3). The radius of rotation of the subepicardium is

greater than that of the subendocardium. The subepicardium consequently provides greater torque than the subendocardium, as a result of which the rotation of the subepicardium is significantly expressed. Fig. 2 Myocardial contraction and rotation. When myocardial fibers on the subepicardial side contract, clockwise rotational torque is produced at the base and counterclockwise rotational torque at the apex. When myocardial fibers on the subendocardial side contract, … Fig. 3 Opposite rotation at the base and Oxymatrine apex. Subepicardial radius is larger than subendocardial radius (r2 > r1). Therefore, subepicardial rotational torque is larger than subendocardial rotational torque (R2 > R1). Why is Twist Motion Necessary? The degree of shortening of myocardial fibers is of the order of 15-20% at most. If ejection was simply the result of contraction of myocardial fibers, the ejection fraction would be 15-20%, whereas the actual ejection fraction of the human heart is 60-70%. This is due to the involvement of twisting.