Distribution of molecular function Gene Ontology terms associated with HBV-human protein interactions Additional file 1, Table S8. LDC000067 mouse Functional analysis of the HHBV distribution and enrichment in cellular pathways using KEGG annotations. (XLS 460 KB) References 1. Kao JH, Chen DS: Global control of hepatitis B virus infection. Lancet Infect Dis 2002, 2: 395–403.PubMedCrossRef 2. Park NH, Song IH, Chung YH: Chronic hepatitis B in hepatocarcinogenesis. Postgrad Med J 2006, 82: 507–515.PubMedCrossRef 3. Huang TJ, Lu CC, Tsai JC, Yao WJ, Lu X, Lai MD, Liu HS, Shiau AL: Novel autoregulatory function of hepatitis B virus M protein on surface gene expression. J Biol Chem 2005, 280: 27742–27754.PubMedCrossRef

4. Roberts LR, Gores GJ: Hepatocellular selleck chemicals carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 2005, 25: 212–225.PubMedCrossRef 5. Barone M, Spano D, D’Apolito M, Centra M, Lasalandra C, Capasso M, Di Leo A, Volinia S, Cilengitide order Arcelli D, Rosso N, et al.: Gene expression analysis in HBV transgenic mouse liver: a model to study early events related to hepatocarcinogenesis. Mol Med 2006, 12: 115–123.PubMedCrossRef 6. Tew KL, Li XL, Tan SH: Functional centrality: detecting lethality of proteins in protein interaction networks. Genome Inform 2007, 19: 166–177.PubMedCrossRef 7. Calderwood MA, Venkatesan

K, Xing L, Chase MR, Vazquez A, Holthaus AM, Ewence AE, Li N, Hirozane-Kishikawa T, Hill DE, et al.: Epstein-Barr virus and virus human protein interaction maps. Proc Natl Acad Sci USA 2007, 104: 7606–7611.PubMedCrossRef 8. Wang N, Zheng Y, Yu X, Lin W, Chen Y, Jiang Q: Sex-modified effect of hepatitis B virus infection on mortality from primary liver cancer. Am J Epidemiol 2009, 169: 990–995.PubMedCrossRef 9. Settles B: ABNER: an open source tool for automatically tagging genes, proteins and other entity names in text. Bioinformatics 2005, 21: 3191–3192.PubMedCrossRef 10. Rebholz-Schuhmann D, Arregui M, Gaudan S, Kirsch H, Jimeno A: Text processing through Web services: calling Whatizit. Bioinformatics Mannose-binding protein-associated serine protease 2008, 24: 296–298.PubMedCrossRef 11. von Mering

C, Jensen LJ, Snel B, Hooper SD, Krupp M, Foglierini M, Jouffre N, Huynen MA, Bork P: STRING: known and predicted protein-protein associations, integrated and transferred across organisms. Nucleic Acids Res 2005, 33: D433–437.CrossRef 12. Ashburner M, Lewis S: On ontologies for biologists: the Gene Ontology–untangling the web. Novartis Found Symp 2002, 247: 66–80. discussion 80–63, 84–90, 244–252PubMedCrossRef 13. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA: Identifying biological themes within lists of genes with EASE. Genome Biol 2003, 4: R70.PubMedCrossRef 14. Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, Katayama T, Kawashima S, Okuda S, Tokimatsu T, Yamanishi Y: KEGG for linking genomes to life and the environment. Nucleic Acids Res 2008, 36: D480–484.PubMedCrossRef 15.