Conclusions Our results confirm the role of PKCε as an oncogene in RCC, especially in the subtype of clear cell, suggesting that PKCε might be a potential treatment target for this disease, which warrants verification in further studies. Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (No. 30872584, 81071760, 30772503); Guangdong Natural Science Foundation (No. 8251008901000018); Sun Yat-sen Innovative Talents Cultivation Program for Excellent Tutors (No. 80000-3126205); and Science and Technology Planning Project of Guangdong Province, China (No. 2011B050400021,

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