Conclusion: LMV always develops in young women with high SLEDAI score. It usually coincides with other system involvement especially ureterohydronephrosis

and interstitial cystitis. Abdominal computed tomography scans are helpful for diagnosis. The prognosis of LMV is poor. Once diagnosed, corticosteroids and immunosuppressant should be Tigecycline mw prescribed promptly to improve outcomes. Key Word(s): 1. Lupus; 2. Vasculitis; 3. Pyelectasis; Presenting Author: XIUJING ZHANG Additional Authors: XUELIAN XIANG, LEI TU, XIAOPING XIE, XIAOHUA HOU Corresponding Author: XIAOHUA HOU Affiliations: Division of Gastroenterology, Union Hospital of Huazhong University of Science

and Technology; Division of Gastroenterology, Union Hospital of Huazhong University of Science and Technology Objective: Most recent studies using high resolution manometry (HRM) were based on supine liquid swallows. This study was to evaluate the differences in esophageal motility for liquid and solid swallows in the upright and supine positions, and to determine the percentages of motility abnormalities in different states. Methods: Twenty-four asymptomatic volunteers and 26 patients with gastroesophageal reflux disease (GERD) underwent high-resolution manometry (HRM) using a 36-channel manometry catheter. The peristalsis of 10 water buy PLX4032 and 10 steamed bread swallows were recorded in both supine and upright positions. Integrated relaxation pressure (IRP), contractile front velocity

(CFV), distal latency (DL) and the distal contractile integral (DCI) were investigated and comparisons between postures and boluses were analyzed. Normative ranges from the healthy volunteers were investigated. Abnormal peristalsis of patients was assessed applying the corresponding normative values. Results: In total, 829 swallows from healthy volunteers and 959 swallows from patients were included. (1) The upright position provided lower IRP, shorter DL and weaker DCI than the supine position. (2) MCE In the comparison of liquid swallows, the mean for CFV was obviously reduced while DL and DCI were increased in solid swallows. (3) The supine position detected more hypotensive peristalsis than the upright position with water swallows (P = 0.041). The upright position provided more rapid and premature contraction than the supine position but there was no statistically significant difference. Conclusion: Supine solid swallows occur with more hypotensive peristalsis. Analysis should be based on normative values from the corresponding posture and bolus results from the controls. Key Word(s): 1. manometry; 2. posture; 3. bolus consistency; 4.