Certain imaging modalities such as magnetic resonance imaging, tr

Certain imaging modalities such as magnetic resonance imaging, transcranial ultrasound, and single-photon emission computed tomography can be useful in making diagnostic decisions in some cases of PD. Devaki Shilpa Surasi, Patrick J. Peller, Zsolt Szabo, Gustavo Mercier, and Rathan M. Subramaniam The clinical diagnosis of Parkinson disease (PD) is difficult, as several other neurodegenerative and basal ganglia disorders have similar clinical presentations. Dopamine transporter single-photon emission computed tomography has been proposed as possible diagnostic tool to help

differentiate idiopathic PD from essential tremor and other disorders that present with parkinsonian symptoms. In addition, it is valuable in the diagnosis of dementia with Lewy bodies, differentiating Selumetinib ic50 it from other causes of dementia such as Alzheimer disease. Shichun Peng, Doris J. Doudet, Vijay Dhawan, and Yilong Ma This article discusses the current use of PET imaging in the evaluation of dopamine function in Parkinson disease (PD). The article reviews the major radioligands targeting dopaminergic systems in patients with parkinsonian disorders. The primary objective is to show the novel

clinical applications of molecular imaging in the diagnosis and assessment of motor and nonmotor symptoms in PD.

Index  487 “
“Li Q, Zhou XD, Kolosov VP, Perelman JM. Sunitinib molecular weight Nicotine suppresses inflammatory factors in HBE16 airway epithelial cells after exposure to cigarette smoke extract and lipopolysaccharide. Transl Res 2010;156:326-34. In our December 2010 publication in Translational Research, we incorrectly stated that cigarette JAK inhibitor smoke extract (CSE) was “supplied by Professor C-H Cho (Department of Pharmacology, University of Hong Kong).” Although Dr Cho prepared the CSE samples, he did not directly provide us with them. Instead, they were obtained by Dr Zhou who had access to the samples while a research fellow at Hong Kong University from 2005 to 2006. “
“Chronic obstructive pulmonary disease (COPD) is a complex systemic disease, that until recently, was underrecognized, underappreciated, and poorly understood. Bonet first described COPD as early as 1679 when he discussed “voluminous lungs,” and yet it wasn’t until the 1960s that physicians began to create formalized definitions of the clinical syndrome they were encountering.1 These initial definitions focused on either clinical characteristics (such as cough and dyspnea) or anatomic features (such as enlargement of alveolar spaces) and, in some sense, neglected expanded features that could be useful in identifying and understanding the disease.

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