(C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Guided by the brine shrimp lethality assay, a new cyclitol derivative, sarcotride D (1), was isolated from a marine sponge Sarcotragus species. The structure was established based on NMR and MS analyses.”
“Objectives: Otitis media (OM) is one of the most frequent diseases of childhood, with a minority of children suffering from recurrent
acute otitis media (rAOM) or chronic otitis media with effusion (COME), both of which are associated with significant morbidity. We investigated whether the microbiological profiling could be used to differentiate between these two conditions.
Methods: Children up to five years selleckchem of age, with rAOM (n = 45) or COME (n = 129) and scheduled for tympanostomy Stattic nmr tube insertion were enrolled in a prospective study between 2008 and 2009. Middle
ear fluids (n = 119) and nasopharyngeal samples (n = 173) were collected during surgery for bacterial culture and PCR analysis to identify Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, and to detect 15 distinct respiratory viruses.
Results: The occurrence of bacterial and viral pathogens in middle ear fluids did not significantly differ between patients suffering from rAOM and COME. In both patient cohorts, H. influenzae and rhinovirts were the predominant pathogens in the middle ear and nasopharynx. Nasopharyngeal carriage with two or three bacterial pathogens was associated with the presence of bacteria in middle ear fluid (P = 0.04). The great majority of the bacteria isolated from middle ear fluid were genetically identical to nasopharyngeal isolates from the same patient.
Conclusions: Based on these results, we propose that the common perception that rAOM is associated with recurrent episodes of microbiologically mediated AOM, BMS-777607 datasheet whereas COME is generally a sterile inflammation, should be reconsidered. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“A new azorellane diterpenoid has been isolated and identified from the aerial parts of Azorella madreporica Clos.
The structure of 1 was established by one- and two-dimensional NMR techniques.”
“Objective: The purpose of this study was to evaluate and compare the demographic characteristics of maxillofacial fractures between children and adolescents.
Methods: The sample was composed of all children (less than 12 years) and adolescents (between 13 and 18 years old) who presented with maxillofacial fractures during a 10-year period (2000-2009). The age, gender, time of injury, mechanism of trauma, location and pattern of fracture, associated injuries, and treatment methods were recorded and analyzed. Data analysis included Chi-Square test, Fisher exact test. p less than 0.05 was considered significant.
Results: Seventy-nine children (male-to-female ratio, 1.63:1) and 113 adolescents (male-to-female ratio, 3.52:1) sustained 389 maxillofacial fractures. Children were more involved in falls compared to adolescents (44.3% versus 23.