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Lal P, Gallagher M, O’Dwyer P, Wilner K, Chen I, Schwartz G: Treatment of growing teratoma syndrome. N Engl J Med 2009, 360:423–424.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions CK have made substantial contributions to acquisition of data. WY participated in the design of the study and performed the statistical analysis. BX participated in its design and drafted the manuscript. All Clomifene authors read and approved the final manuscript.”
“Introduction More patients with early breast cancer have been diagnosed with the development of screening techniques [1]. Following adjuvant chemotherapy and endocrine therapy can significantly improve disease-free survival (DFS) and overall survival (OS) in early breast cancer patients [2–4]. However, both adjuvant chemotherapy and endocrine therapy cause bone loss to these

patients. Patients with amenorrhea after chemotherapy [5, 6] and postmenopausal patients receiving aromatase inhibitors (AIs) are at high risk of bone loss [3, 4, 7–9]. Zoledronic acid (ZOL) can prevent bone loss in early breast cancer patients [10]. Furthermore, ZOL also has antitumor and antimetastatic properties. The previous meta-analysis [11] suggested that the use of ZOL was associated with a statistically significant lower risk for disease recurrence. In addition, ZOL has several potential advantages compared to the oral bisphosphonates, including good bioavailability, gastrointestinal tolerance, and adequate compliance [12]. Thus, less adverse effects, such as gastrointestinal disorders and vascular disorders, were caused by ZOL [12].