Attendees will leave this session with practical knowledge of cutting-edge therapies for chronic hepatitis C. Leon Schiff State-of-the-Art Lecture Tuesday, November 5 10:30 – 11:00 AM Hall E/General Session HCV Therapeutics in the Post-Interferon Era: More than the Sum of its Parts?
SPEAKER: Robert T. Schooley, MD MODERATOR: Adrian M. Di Bisceglie, MD Learning Objectives: Discuss the role of innate immune evasion Trametinib mechanisms of HCV in establishing and maintaining chronic infection in the liver Identify the potential implications of viral dynamics and replication fidelity as barriers to the pharmacologic cure of HCV infection Describe mechanisms that may account for the better than expected results to date of directly acting agents in the treatment of infection The Leon Schiff State-of-the-Art Lecture honors Dr. Schiff and recognizes the work he did to elevate the study and practice of hepatology to the discipline it is today. The restricted fund supporting this lecture ensures that future hepatologists will have a distinct platform from which to provide their valuable insights at The Liver Meeting®. AASLD gratefully acknowledges
the National Genetics Institute for its generous support of this fund. Parallel Session Parallel 32: Alcohol Induced Mechanisms of Injury and Therapeutic Targets Tuesday, November 5 11:15 AM -12:45 PM Room 145 MODERATORS: Hidekazu Tsukamoto, DVM, PhD Min You, PhD 11:15 AM 217: Notch mediates macrophage M1 activation in ASH via metabolic reprograming PF-02341066 in vivo Jun selleck inhibitor Xu, Feng Chi, Samuel W. French, Hidekazu Tsukamoto 11:30 AM 218: Hepatocyte-derived metabolic danger signals, extracellular ATP and uric acid, synergistically induce inflammatory
cell activation and represent therapeutic targets in alcoholic liver disease Jan Petrasek, Arvin Iracheta-Vellve, Shashi Bala, Karen Kodys, Evelyn A. Kurt-Jones, Gyongyi Szabo 11:45 AM 219: The role of stem cell derived microvesicles and microRNAs during alcoholic liver injury Phillip Levine, Kelly McDaniel, Shannon S. Glaser, Heather L. Francis, Yuyan Han, Julie Venter, Taylor Francis, Chang-Gong Liu, Hidekazu Tsukamoto, Gianfranco Alpini, Fanyin Meng 12:00 PM 220: Adipocyte-Specific Lipin-1 Deficiency Disturbs Adiponectin Signaling and Aggrevates Alcoholic Fatty Liver in Mice Huquan Yin, Xiaomei Liang, Joanne M. Ajmo, Brian Finck, Min You 12:15 PM 221: Binge Drinking and Weight Gain Accentuate Eicosanoid Mediated Inflammation and Oxidative Injury in Alcoholic Liver Disease – Novel Pathophysiologic Insights from Lipidomic Analysis Puneet Puri, Jun Xu, Faridoddin Mirshahi, Hae K Min, Tommy Pacana, Vaishali Patel, Kalyani Daita, Terhi Vihervaara, Riikka Katainen, Kim Ekroos, Andrew R. Joyce, Hidekazu Tsukamoto, Arun J. Sanyal 12:30 PM 222: Genetic Polymorphisms of Galectin-9 (Gal-9) Associated with Risk of Developing Alcoholic Liver Disease (ALD) in Humans Hugo R.