184 Ileal pouch-anal anastomosis also requires expertise FG-4592 mw and centralization of experience to fewer treatment centers can be recommended. Acute complications of

IPAA include anastomotic leak, sepsis, injury to local structures including pelvic nerves. Because fecundity can be impaired with IPAA in young female patients, ileorectal anastomosis should be considered. Also, in the elderly and females with delivery-related injury during childbirth, anal sphincter may be weakened and IPAA may be complicated by fecal incontinence. Pouchitis is a non-specific inflammation of the ileal reservoir and the most common complication of IPAA in patients with UC. Screening tests according to local practice for hepatitis B virus infection [III,A], human immunodeficiency virus [III,C], and TB [II-3,A] need to be considered prior to commencement of corticosteroids, immunomodulators and/or biologic agents. Vaccination, prophylaxis or therapy should be performed in appropriate clinical settings. [III,C] Level of agreement: a-19%, b-81%, c-0%, d-0%, e-0% Quality of evidence and Classification of recommendation: as above Hepatitis B virus infection.  The prevalence of hepatitis B virus (HBV) infection is higher in the Asia-Pacific region than Western countries. The withdrawal of immunosuppressive

EPZ-6438 order therapy can result in severe HBV reactivation thus preemptive treatment with a nucleoside or nucleotide analogue may suppress viral replication on initiation of immunosuppression. Case reports of HBV reactivation IMP dehydrogenase are described following the use of IFX, AZA/ 6-MP with or without corticosteroids and rarely results in fulminant hepatic failure.185,186 In the Asia-Pacific region, HBV serology should be performed in all IBD patients as HBV-negative and HBV surface-antibody negative patients can receive vaccination, and HBV surface antigen-positive patients can be treated with anti-viral agents prior to immunosuppression.

Hepatitis B virus anti-core-antibody-positive surface antigen-negative patients require close monitoring for possible HBV reactivation and hepatitis flare.187 Tuberculosis.  The prevalence of tuberculosis (TB) is high in many parts of the Asia-Pacific region. Intestinal TB is a differential diagnosis in newly diagnosed IBD. Screening for TB is mandatory in Asian countries and high-risk cases require anti-TB treatment or chemoprophylaxis with isoniazid according to acceptable local practice.117 Screening strategies differ according to endemic TB prevalence and BCG vaccination practice but can include chest radiograph, tuberculin skin testing, human mycobacterium-specific interferon gamma assays, and high vigilance in the development of breakthrough infection. Other opportunistic infections.