“
“Linear low-density polyethylene (LLDPE)/sepiolite nanocomposites were prepared by melt blending using unmodified ACP-196 solubility dmso and silane-modified sepiolite. Two methods were used to modify sepiolite: modification before heat mixing (ex situ) and modification during heat mixing (in situ). The X-ray diffraction results showed that the position of the main peak of sepiolite remained unchanged during modification step. Infrared
spectra showed new peaks confirming the development of new bonds in modified sepiolite and nanocomposites. SEM micrographs revealed the presence of sepiolite fibers embedded in polymer matrix. Thermogravimetric analysis showed that nanocomposites exhibited higher onset degradation temperature than LLDPE. In addition, in situ modified sepiolite nanocomposites exhibited higher thermal stability than ex situ modified sepiolite nanocomposites. The ultimate tensile strength and modulus of the nanocomposites were improved; whereas elongation at break was reduced. The higher crystallization temperature of some nanocomposite formulations revealed a heterogeneous nucleation effect of sepiolite. This can be exploited for the shortening of cycle time during processing. (C) 2011 Wiley Periodicals,
Inc. J Appl Polym Sci 123: 1718-1723, 2012″
“Background: The Anopheles gambiae gSG6 is an anopheline-specific salivary protein which helps female mosquitoes to efficiently feed www.selleckchem.com/products/ly2157299.html on blood. Besides its role in haematophagy, gSG6 is immunogenic and elicits in exposed individuals an IgG response, which may be used as indicator of exposure to the main African malaria vector A. gambiae. However, malaria transmission in tropical Africa is sustained by three main vectors (A. gambiae, Anopheles arabiensis and Anopheles funestus) and a general marker, reflecting
exposure to at least these three Cyclopamine purchase species, would be especially valuable. The SG6 protein is highly conserved within the A. gambiae species complex whereas the A. funestus homologue, fSG6, is more divergent (80% identity with gSG6). The aim of this study was to evaluate cross-reactivity of human sera to gSG6 and fSG6.
Methods: The A. funestus SG6 protein was expressed/purified and the humoral response to gSG6, fSG6 and a combination of the two antigens was compared in a population from a malaria hyperendemic area of Burkina Faso where both vectors were present, although with a large A. gambiae prevalence (> 75%). Sera collected at the beginning and at the end of the high transmission/rainy season, as well as during the following low transmission/dry season, were analysed.
Results: According to previous observations, both anti-SG6 IgG level and prevalence decreased during the low transmission/dry season and showed a typical age-dependent pattern. No significant difference in the response to the two antigens was found, although their combined use yielded in most cases higher IgG level.