Then the dose of prednisone was reduced to 10 mg. After 4 months, he found his finger nails were atrophic again and abdominal mild discomfort, without diarrhea. Colonoscopy revealed recurrence of the polys in March 2011. He was treated again with prednisone, at a daily dose of 20 mg.The symptoms had subsided soon. In September 2011, he underwent colonoscopy although he had no significant clinical manifestation. Unfortunately, the polyp in sigmoid colon was cancerated. Conclusion: From this case, we take lessons: 1) Malignant transformation of CCS polyps may occur, the risk of colorectal cancer may warrant aggressive

screening in CCS patients, and endoscopic surveillance is very important every six months. 2) After the diffuse inflammatory polyps have responded MK-1775 in vitro to steroid therapy, other existing adenomas need endoscopic treatments which can disease the possibility of neoplastic transformation. Key Word(s): 1. Cronkhite-Canada; 2. malignant; Presenting Author: CHENG-YU LIN Additional Authors: CHENG-TANG CHIU, WEY-RAN LIN, CHI-HUAN WU Corresponding Author: CHENG-YU LIN Affiliations: Chang Gung Memorial Hospital, Linkou; Chang Gung Memorial Hospital, Linkou; Chang Gung Memorial Hospital, Linkou; Selleck PD-1 inhibitor Chang Gung Memorial Hospital, Linkou Objective: Clostridium difficile infection places a high burden on health-care system and is one of the major concerns of medical

doctor in recent decades. Pseudomembranous colitis, generally caused by Clostridium difficile, is characterized by the formation of elevated plaques and pseudomembranes. The aim of this study was conducted this website to evaluate the clinical presentation of pseudomembranous colitis. Methods: A total of 22317 consecutive subjects who received diagnostic lower

gastrointestinal endoscopy between 2009∼2012 in a single medical center of north Taiwan were reviewed. Patients who were diagnosed as pseudomembranous colitis endoscopically combined with pathological or microbiological proved were included. The data collected included gender, age, clinical presentation, co-morbidities, endoscopic features and medication history were analyzed. Results: A total of 29 cases with pseudomembranous colitis were analyzed and 14 (48.3%) of them presented with watery diarrhea and 11 ones (38%) presented with bloody stool. The mean age was 69.9 years old and there were 10 (34.5%) patients had recent proton-pump inhibitor use, 17 ones (58.6%) had antibiotics usage. Nine (31%) of them were community acquired, only one (11.1%) of them present as watery diarrhea and none had recent antibiotics usage. Conclusion: Patients with pseudomembranous colitis have variable clinical presentation and the most discriminating symptoms were watery diarrhea and bloody stool. Patient had pseudomembranous colitis from community may have different presentation and etiology. Key Word(s): 1. Pseudomembranous; 2. Colitis; 3. C.