It generates a health profile made up of 5 domains (mobility, self care, anxiety/depression, usual activities and pain/discomfort), each one with three levels of severity. It also consists of a visual analogue scale Lumacaftor datasheet (EQ-5D VAS) which measures overall HRQoL in a range from 0 (worst imaginable health state) to 100 (best imaginable health state). The baseline HRQoL data was analyzed dividing the patients in sub-groups according to the most recently diagnosed and most severe condition. The results reported below

focus on the mean VAS. We enrolled 3,217 patients, 64.8% male, aged 19–91 (median=61) years; 95.0% of them filled in the EQ-5D at baseline. Patients in the HCC group Nutlin-3 order were 22.6%, those with compensated cirrhosis were 21.2%, HCV 20.9%, decompensated cirrhosis 10.3%, HBV 9.5%. The HBV group reported the best HRQoL

with a mean EQ-5D VAS of 77.8. NAFLD/NASH, HCV and PSC patients had a similar HRQoL with a mean EQ-5D VAS between 76.5 and 75.1. While, compensated cirrhosis and PBC had a slightly worsen values (74.5 and 74.0, respectively). HCC and decompensated cirrhosis showed a mean EQ-5D VAS of about 69.0. At least, AIH and listed for liver transplant patients reported the worst HRQoL levels than the other sub-groups (67.7 and 67.0, respectively). In conclusion, EQ-5D is well accepted by the patients and accurately reflects the changes in HRQoL related to the clinical severity of LDs. Understanding the different impact of LDs on the patients’ HRQoL could help physicians and decision makers to better estimate the burden of these conditions and to improve the quality of care. 上海皓元 Disclosures: Vincenzo Mazzaferro – Advisory Committees or Review Panels:

Bayer; Grant/Research Support: Nordion; Speaking and Teaching: Merck Serono S.p.A. Michele Colledan – Advisory Committees or Review Panels: novartis The following people have nothing to disclose: Paolo A. Cortesi, Luciana Scalone, Roberta Ciampichini, Paolo Cozzolino, Giancarlo Cesana, Lorenzo G. Mantovani, Stefano Okolicsanyi, Antonio Ciaccio, Matteo Rota, Maria Gentiluomo, Marta Gemma, Antonella Grisolia, Patrizia Pontisso, Patrizia Burra, Mario U. Mondelli, Luca Fabris, Stefano Fagiuoli, Maria G. Valsecchi, Luca S Belli, Mario Strazzabosco PURPOSE: The setup of the operating room (OR) and preparation of the patient for surgery are critical steps in assuring safety and quality of care during the highly complex process of living donor liver transplantation (LDLT). We studied the systems and processes involved in the preparations in the OR prior to incision using industrial engineering Lean Six Sigma principles. METHODS: Data from the A2ALL Patient Safety System Improvements in Living Donor Liver Transplantation Study (R01 DK090129) were used.