Also, Reactive Oxygen Species are involved Lenalidomide CAS in many physiological functions and colorectal pathological pro cesses, Inhibitors,Modulators,Libraries such as Crohns disease, ulcerative colitis, and colorectal cancer. Therefore, there is an in creasing interest in the potential effects of exogenous antioxidants on the prevention of oxidative gastrointes tinal disorders. Recently, Up regulation Inhibitors,Modulators,Libraries of endogenous antioxidant and phase II antioxidant enzymes by Nrf2 has emerged as a novel target for the prevention of CRC since it is currently well accepted that chronic inflamma tion is a contributing factor in 15 20% malignancies in cluding CRC and that this inflammation can be attributed to a number of factors including oxidative stress, reactive oxygen species and reactive nitrogen species.

Phase II metabolizing detoxifying and antioxidant defense enzymes, antioxidants, and ATP Inhibitors,Modulators,Libraries dependent drug efflux pumps are regulated by cis acting regulatory element the antioxidant responsive element TGACNNNGC 3 , and Nrf2, a member of the Capn Collar family of transcription factors, which mainly regulates transcriptional activation through the ARE. The Nrf2ARE signal pathway has been consid ered to protect cells against carcinogenesis and attenuate cancer development via neutralization of ROS or carcino gens. Nrf2 deficient mice were more susceptible to carcinogenesis, suggesting that Nrf2ARE mediates the phase II detoxifying enzymes and antioxidant proteins in the inactivation of chemical carcinogens. Functional foods act as antioxidant nutrients and pro tect against many human chronic diseases by combating reactive oxygen species generation.

As diet antioxidants, flavonoids, polyphenolic compounds occur ring Inhibitors,Modulators,Libraries naturally in the plant kingdom such as vegetables, fruits and plant derived beverages such as tea, cocoa, and red wine, display a wide range of pharmacological proper ties, including anti carcinogenesis and anti inflammation. Flavonoids also exert a potent antioxidant activity, acting as reactive oxygen species scavengers, metal ions chelators and free radical reaction terminators. However, they can also act indirectly as antioxidants stimulating phase II detoxifying and antioxidant defense enzymes to preserve cellular integrity and tissue homeo stasis. Digitoflavone, a flavone subclass of flavonoids, vegetables and fruits such as celery, parsley, broccoli, onion leaves, carrots, peppers, cabbages, apple skins, and chrysanthe mum flowers are digitoflavone rich.

Plants rich in digitoflavone have been used as Chinese traditional medi cine for hypertension, inflammatory diseases, and cancer. Also, it has been known to have chemopreventive ef fects Inhibitors,Modulators,Libraries against malignant tumors in vivo. Our recent study has found digitoflavone induce G2 phase cell cycle arrest, inhibit angiogenesis and down regulate expression of NF Pazopanib ��B. Much attention has been focused on digitoflavone due to its strong antioxidant and radical scavenging properties.