The measured values of TNF-R1 were converted into multiples of the normal median (MoM) and the MoM values in the PE and control groups were CH5183284 supplier compared.
Results: The median MoM TNF-R1 was significantly increased at both 11-13 weeks (1.094 MoM versus 1.003 MoM) and at 30-33 weeks (1.101 MoM versus 1.006 MoM). In screening for PE by a combination of maternal characteristics and serum TNF-R1 at 30-33 weeks, the estimated detection rates of PE at false positive rates of 5% and 10% were 32.0% and 40.0%, respectively.
Conclusion: Screening by maternal characteristics and serum TNF-R1 at 30-33 weeks could be effective in identifying some of the cases that will subsequently develop PE.”
“BACKGROUND:
Fusarium solani pisi cutinase was microencapsulated in reversed micelles of bis(2-ethylhexyl) sodium sulfosuccinate (AOT) in isooctane for the production of alkyl esters, known as biodiesel; its stability in this system was also evaluated. Results using cutinase wild type and three mutants, L153Q, T179C and S54D, were compared.
RESULTS: There is a loss of 45% of cutinase wild type activity when incubated in the micellar system for 3 h, indicating a denaturing effect of AOT towards the enzyme, and furthermore a loss of 90% of the activity is observed in the presence of methanol with only
10 min of incubation. In contrast, an improvement of cutinase performance was achieved when incubated with ethanol or butanol, indicating that these alcohols have a protective role regarding GSK1904529A the enzyme. Mutant T179C displayed high stability in the presence of methanol with an activity loss of only 16%.
CONCLUSIONS: Mutant T179C presented not only high resistance to the denaturing effect of AOT but also high stability
in the presence of methanol. This is a promising biocatalyst for a continuous process. (C) 2010 Society of Chemical Industry”
“Objective: To assess the role of the referees in assisting the peer review process of systematic reviews and meta-analyses.
Methods: A one-page questionnaire was mailed to 1391 referees of two journals, the American Journal of Obstetrics and Gynecology and Obstetrics and Gynecology. The referees were asked how often they Selleckchem MAPK Inhibitor Library verified by their own independent analysis 11 key items related to the methodology and statistical analysis of systematic reviews and meta-analyses. Response categories included “”always”", “”frequently”" (>50% of the time), “”infrequently”" (<= 50% of the time) and “”never”". A second and a third mailing was sent to the non-respondents.
Results: 42 mailings were returned because of change of address. Of the remaining 1349 referees, 272 responded (response rate 20%). Of the 272 respondents, 159 (58%) had previously reviewed articles dealing with systematic reviews or meta-analyses.