Methods: Participants: Among 397 JNSCS participants who were diagnosed with new-onset primary nephrotic syndrome by kidney biopsy in 57 nephrology centers between 2008 and 2010, the present study included 280 (70.5%) patients who had ≥3.5 g/day of baseline urinary protein (or urinary protein/creatinine ratio (UPCR)) at initiating immunosuppressive therapy. Outcome:
Partial remission (PR) defined as <3.5 g/day of urinary protein (or UPCR). Statistical analysis: Optimal time period was identified using two methods. In Method 1, the optimal time period was 90% and 95 % of time period between baseline and PR in patients achieving PR during the entire observational period. In Method 2, the time period reaching 90% and 95% of the final cumulative probability of PR was calculated using Kaplan-Meier Selleck AZD0530 methods including both patients BMS-777607 with and without PR. Results: During 1.6 (1.1–2.1) years of observational period, 131 (98.5%), 84 (85.7%), 24 (80.0%), and 16 (84.2%) patients with minimal-change disease (MCD), membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), and others achieved PR within 8 (5–14), 29 (12–103), 23 (12–37), and 14 (7–22) days of immunosuppressive therapy, respectively (Figure). In method 1, 90% and 95 % of time period to PR were 29 and 59 days in MCD, 207 and 242 days in MN, 25 and 66 days in FSGS, and 30 and 60 days in others, respectively. In method 2, the time period
reaching 90% and 95% of the final cumulative probability of PR were 29 and 59 days in MCD, 211 and 327 days in MN, 66 and 207 days in FSGS, 30 and 60 days in others, respectively. Conclusion: Optimal time period to diagnose resistance to immunosuppressive therapy is 1–2 months in MCD and FSGS whereas ≥6 months in MN. THANIGACHALAM DINESHKUMAR, JEYACHANDRAN DHANAPRIYA, NATARAJAN GOPALAKRISHNAN, RAMANATHAN SAKTHIRAJAN, T BALASUBRAMANIAM Madras Medical College Introduction: Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome, accounting for 10% to 35% of nephrotic syndrome in adults. We intend to study the epidemiological profile, clinicopathologic correlation of primary focal segmental glomerulosclerosis in adults
and its predictors of treatment response. Methods: Adult learn more patients with biopsy proven FSGS between 2006 January and December 2012 were included.Patients with secondary causes of FSGS were excluded. All patients are started on oral prednisolone 1 mg/kg/day after ruling out infections and continued for 6 months, tapered and stopped within one month. All patients received maximal tolerable dose of angiotensin-converting inhibitors or angiotensin II receptor blockers and statins. Results: Among 195 adult patients, 170 were included in the study after applying exclusion criteria. Mean duration of follow up was 4.32 ± 1.2 years. About 65% were males (Male : Female ratio – 1.9:1) Mean age at presentation was 29.2 ± 13.1 years. Nephrotic proteinuria was present in 79% of patients.