Benefits mRNA expression of annexin II and S100A6 in gastric tumor tissue and non tumor tissue The mRNA expressions of annexin II and S100A6 in gastric tumor tissues and corresponding non tumor tis sues have been analyzed employing qRT PCR in a total of 40 pairs of matched tissue specimens. In gastric tumors, the mRNA expression amounts of Annexin II had been larger in cancer tissues than non tumor tissues. The mRNA expres sion amounts of S100A6 had been larger than non tumor tissues. Expression of annexin II and S100A6 in GC and non cancer mucosa Annexin II protein was detected in 18 of 92 human non tumor mucosa, all samples expressed the protein at very low amounts. Annexin II protein was detected in 175 of 436 human gastric cancer circumstances. Large expression of annexin II protein was detected in 133 tumors, and reduced expression was detected in 42 tumors.
Annexin II was overexpressed strongly within the cell membrane of principal cancer and weakly during the cytoplasm of carcinoma cells. S100A6 pro tein was detected in 9 of 92 pan Raf inhibitor human nontumor mucosa, all samples expressed the protein at lower levels. S100A6 protein was detected in 256 of 436 human gastric cancer situations. High expression of S100A6 protein was detected in 183 tumors and minimal expression was detected in 73 tumors. S100A6 was predominantly localized during the cytoplasm, although nu clear staining was also detectable in some samples. Correlation involving annexin II and S100A6 and clinicopathological characteristics The expression of annexin II correlated with age, loca tion of tumor, dimension of tumor, differentiation, histological variety, depth of invasion, vessel invasion, lymph node me tastasis, distant metastasis, and TNM stage but did not correlate with gender.
Beneficial expression of S100A6 correlated with age, loca tion, dimension of tumor, depth of invasion, vessel invasion, lymph node metastasis, distant metastasis and TNM stage, but did not correlate with gender, differentiation or histological style. Elements with attainable prognostic WZ4002 results in gastric carcinoma have been analyzed by Cox regression examination. Statistical analysis showed that depth of invasion, lymph node metastasis, distant metastasis, TNM stage, expression of annexin II and ex pression of S100A6 had been independent prog nostic variables in patients with gastric carcinoma. However, the spot of your tumor, tumor size, histo logical sort, differentiation and vessel invasion had no prognostic value in our Coxs proportional hazards re gression model.
It could relate to sample assortment so it can be important that substantial sample and effectively made multi center scientific studies based on diverse groups are essential to verify our effects. We even more carried out the strati fied analysis in accordance to various TNM stages as well as benefits confirmed that annexin II was an inde pendent prognostic factor in sufferers with gastric auto cinoma.