1 Children living with HIV in low and middle income countries, eligible for ART are less likely than adults to receive it, with ART coverage being 34% for children and 64% for adults in 2012.2 Prevention of mother to child transmission

is key to reducing the HIV-related child mortality and morbidity (see Table 1). Without intervention the risk of MTCT (mother to child transmission) ranges from 20 to 45%.3 In non-breastfeeding populations, with specific interventions the risk of MTCT can be as low as less than 1% and as low as 2–5% in breastfeeding populations.4 Target 3 of the United Nintedanib Nations Programme on HIV/AIDS (UNAIDS) goals for 2015 is to eliminate new HIV infections amongst children by 90% and to substantially reduce AIDS related maternal deaths by 50%.3 and 5 The millennium development goal 4 is to reduce the under 5 mortality by two thirds by 2015.4 Goal 5 aims to reduce maternal mortality by three quarters and have universal access to reproductive health by 2015.6 Millennium Goal 6 aims for the number of new HIV infections to have halved by 2015 and for there to be universal

selleck chemicals llc access to treatment by 2010.4 In the context of the UNAIDS goals and the millennium development goals we are in a critical position to assess current progress and recommit to advance our success in tackling this issue both on national and international levels. In 2011 the countries with the lowest estimated coverage of the most effective regimen were North Africa and the middle east (9%), west and central Africa (26%) and East, South and South east Asia (20%).7 This compares with Europe and central Asia (95%) and sub-Saharan Africa (58%).7 There has been a steady decline of 24% in MTCT in sub-Saharan Africa from 2009–2011.7 There were modest declines in the Caribbean and Oceania, with North Africa and the Middle East yet to show any decline.7 However different countries will have different priorities depending on the nature of their epidemic. For example, the Western Pacific, South East Asia and the Americas focus on the dual elimination

of HIV and congenital syphilis, whereas Eastern Europe targets the IV drug users and their partners as a priority population for improving Orotic acid PMTCT (prevention of mother to child transmission).4 In 2010 the Pan American Health Organisation and UNICEF (United Nation’s International Children’s Emergency Fund) developed strategies for the advancement of elimination of MTCT of HIV and congenital syphilis.6 The aim was to reduce new paediatric cases of HIV to 0.3 per 1000 live births and to reduce congenital syphilis to 0.5 cases per 1000 live births by promoting the integration of HIV, sexual and reproductive health, paediatric, family and community health services.6 It aims to ensure that women have access to rapid diagnostics for both HIV and syphilis and to treatments and monitoring.