Just as language fluency requires knowledge of how to connect words together in a meaningful way, fluency in neuroanatomy requires a comprehensive understanding of the connections between different regions and an interest in connecting structure to function. Nearly 150 years ago, Paul Broca linked brain structure to function in his description of what is commonly known as Broca’s aphasia (Broca, 1861). His description of functional deficits that follow damage to the left ventrolateral

prefrontal cortex were soon followed by Carl Wernicke’s description of language deficits following damage to left posterior temporal cortex (Wernicke, 1874), and the development by Brodmann of the learn more most famous and most commonly known cytoarchitectonic map (Brodmann, 1909). Brodmann’s map attempted to provide a link between our understanding of the brain at the microscopic and macroscopic scales, and today we associate Brodmann’s areas 44 and 45 with the term ‘Broca’s area’. But what about the RG 7204 anatomical

connections? In the human, it is fairly straightforward for neuroanatomists to study cytoarchitectonic divisions in post-mortem brain; however, attempts to use anterograde and retrograde tracers in post-mortem human tissue have not been very successful. For this reason, the gold standard for studying anatomical connections remains experimental tracing studies in animals, especially in the nonhuman primate. Advances in neuroimaging

have provided us with new methods for studying neuroanatomical structure and function, including diffusion tensor imaging methods for examining white matter fiber tracts and functional magnetic resonance imaging methods for examining function. The development of methods for examining functional connectivity using resting state functional connectivity (RSFC) and task-dependent functional connectivity methods extend our ability to map anatomical and functional connectivity in the human. In an article published in this issue of EJN, Clare Kelly and collaborators (Kelly et al., 2010) describe studies linking human brain RSFC data with anatomical tracing studies in nonhuman primates. More specifically, the authors examined the correspondence of patterns of connectivity between areas 6, 44 and 45 and posterior parietal D-malate dehydrogenase and temporal regions in the human, measured with RSFC methods, to anatomical connectivity studies between the homologues of these areas in the macaque monkey, measured in a separate nonhuman primate autoradiographic tracing study by Petrides & Pandya (2009). The studies demonstrate strong correspondence between the connectivity in the human and nonhuman primate. The clustering of anatomical data supports the existence of different functional connectivity patterns for ventral area 6 that are distinct from areas 44 and 45. Ventral area 6 shows strong connections with the rostral supramarginal gyrus of the parietal lobe.