75 mg/kg/hr for the duration of the procedure The interventional

75 mg/kg/hr for the duration of the procedure. The interventional strategy, utilization of adjunct pharmacotherapy, such as glycoprotein IIb/IIIa inhibitors,

and device choice were at the operator’s discretion. Dual antiplatelet therapy was recommended for ≥ 12 months for all patients post procedure. Clinical, procedural, and follow-up data learn more were prospectively collected and stored in a central database. A dedicated data coordinating center performed all data management and analyses. Pre-specified clinical and procedural data and in-hospital complications were obtained from hospital charts reviewed by independent research personnel blinded to the study objectives. Primary source documents were obtained for all events and were used to adjudicate STEMI cases by physicians not involved in the procedures, and who were unaware of the study objectives. The time points and time intervals Veliparib supplier pertaining to STEMI management and system performance were adjudicated and verified by physicians not involved in the study. The institutional review boards at MedStar Washington Hospital Center (Washington, DC) and the MedStar Health Research Institute (Washington, DC) approved this study. Statistical analysis was performed using SAS version

9.1 (SAS Institute Inc., Cary, NC). Continuous variables are presented as mean ± standard deviation (SD) if normally distributed, or median ± interquartile range (IQR) if non-normally distributed. Student’s t test and Wilcoxon rank-sum test were used for comparisons of normally and non-normally distributed continuous data, respectively. Categorical variables are expressed as frequencies and percentage, and compared using chi-square test or Fisher’s exact test through as appropriate. A multivariate logistic regression model was used to determine the independent correlates of DTB > 90 minutes, expressed as odds ratio, with 95% confidence interval. Variables were selected on the basis of overall clinical relevance, with particular attention given to clinical and procedural

factors that may delay time to reperfusion. Variables included self-transport (versus EMS), off-hours presentation (versus on hours), age, female gender, body mass index, diabetes, peripheral vascular disease, prior PCI, prior coronary artery bypass grafting, placement of intra-aortic balloon pump, and American College of Cardiology/American Heart Association type C lesion. A p value < 0.05 is considered statistically significant. A total of 309 consecutive STEMI patients who underwent primary PCI were analyzed, of which 226 arrived by self-transport, and 83 were transported by EMS. The baseline and procedural characteristics in both groups were similar. (Table 1 and Table 2). The majority of patients from both groups presented to the ED during off hours. A significantly higher percentage of EMS-transported patients achieved the time goals of DTB < 90 minutes and DTB < 120 minutes compared to self-transported patients. (Fig.

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